valium half life elderly
More recent studies have indicated that excessive benzodiazepine dosage may be a more salient factor than drug half-life. Furthermore alterations in phar.
Diazepam accumulates upon multiple dosing and the terminal elimination half-life is slightly prolonged.
. The risk is increased in those taking concomitant sedatives including alcohol and in the elderly. Factors That Influence How Long Valium Stays in Your System. There is a high prevalence of long-term benzodiazepine use among elderly persons persons aged 65 years or older who account for 125 percent of the general.
Oxazepam has a half-life of 4-15 hours while temazepam has a half-life of 8-22 hours. Oxazepam and diazepam were compared in healthy elderly volunteers. In children 3 - 8 years old the mean half-life of diazepam has been reported to be 18 hours.
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The half-life of Valium will vary depending on age gender dosage and underlying health issues. Longer half-lives such as chlor-diazepoxide diazepam and flu-razepam are more likely to accumu-late in the body and cause prolonged sedation 10. In children 3 - 8 years old the mean half-life of diazepam has been reported to be 18 hours.
To determine how long the chemical diazepam within Valium stays in your system after stopping it is necessary to review its elimination half-life. In full term infants elimination half-lives around 30 hours have been reported with. The pharmacokinetics of diazepam were examined in seven young 20-30 years and six elderly 60-75 years males prior to and also after chronic oral dosing of diazepam.
Drug Abuse And Dependence. Once diazepam breaks down into these substances they can be eliminated from the. Absorption of diazepam was faster than oxazepam and onset of clinical effects were more pro.
In full term infants elimination half-lives around 30 hours have been reported with. Diazepam is subject to Schedule IV control under. 48 According to Beers 1997 criteria for determining.
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